Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
نویسندگان
چکیده
منابع مشابه
Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski Insights on Ski-Mediated Repression of TGF-β Signaling
The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with tha...
متن کاملTo Ski or Not to Ski on Replaced Hips
A report on two friends Since the outbreak of peace and prosperity in Europe forty years ago skiing has become one of the most popular pastimes , and now many of its ageing devotees have had their hips replaced, they are still sound in wind, are they also sound in limb? They feel physically restored, the snows and the slopes beckon, should they accept the challenge or should 'wiser councils pre...
متن کاملTGF-β Repressors SnoN and Ski Are Implicated in Human Colorectal Carcinogenesis
Background: The TGF-β signaling repressors SnoN and Ski have been critically implicated in human cancer. Methods: To explore the role of SnoN and Ski in the development and progression of colorectal cancer we examined their protein expression profile by immunohistochemistry in a series of human colorectal adenomas, carcinomas and lymph node metastases. The mRNA expression of SnoN was also quant...
متن کاملSki injury predictive analytics from massive ski lift transportation data
Ski injury research is traditionally studied on small-scale observational studies where risk factors from univariate and multivariate statistical models are extracted. In this article, a large-scale ski injury observational study was conducted by analyzing skier transportation data from six consecutive seasons. Logistic regression and chi-square automatic interaction detection decision tree mod...
متن کاملGeneralizations of Ski-Rental
Suppose you want to start a new hobby: skiing. In the ski shop, they give you the options to either rent skis or buy skis. If you know a priori how many days you will be skiing, then you can easily compute whether you should rent or buy right from the first day. This is an example of offline problems—all information is given at once, even future information. In the real world, you would not kno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.63545